Non sedating tricyclics
Subclasses include: the tricyclic antidepressants (e.g., amitriptyline and doxepin); the serotonin-specific reuptake inhibitors (SSRI) including fluoxetine (Prozac); monoamine oxidase inhibitors (MAOIs), including phenelzine (Nardil); and several new drugs such as venlafaxine (Effexor) and nefazodone (Serzone). (2004) cites EMCDDA (1999) who reviewed controlled experimental studies and concluded that impaired performance is associated with the use of most sedative tricyclic antidepressants.New-generation antidepressants do not seem to interfere with performance, except when used at higher doses.are there really any antidepressants that primarily work against generalized anxiety that are not sedating?I don't think one exist, if one does it's in the approval process, I hear there is one that starts with a v in france ..sure. Are they sedating.i have tried an NRI, an SSRI, and tricyclics.I am not depressed but hyperfocus when I'm bored or when my stims are tapering down regarding therapeutic benefits.I previously thought maybe an antidepressant could be beneficial as an adjunct to help give me a smoother or calmer level of focus but I think I could be wrong.Antidepressants are prescribed most often for clinical depression and severe cases of depression.
The effect of antidepressants on driving behavior was assessed with the standard deviation of lateral position (SDLP) test.
Tricyclic antidepressants (often abbreviated to TCAs) are a class of drugs that are traditionally used to treat depression; however, they may also be used in the treatment of other mood disorders, to relieve chronic nerve-related pain, to reduce bed-wetting, to manage obsessive compulsive behaviors, and to prevent migraines.
TCAs increase levels of norepinephrine and serotonin by inhibiting their reuptake, and also block the actions of another neurotransmitter, acetylcholine. Affinities for these neurotransmitters differ among various TCAs, which explains why some TCAs are more effective than others for certain conditions or are more likely than others to cause side effects such as constipation, dry mouth, and sedation.
Although TCAs are sometimes prescribed for depressive disorders, they have been largely replaced in clinical use in most parts of the world by newer antidepressants such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs) and norepinephrine reuptake inhibitors (NRIs).
Adverse effects have been found to be of a similar level between TCAs and SSRIs.