Non sedating antidepressants

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Medication summary Always combine pharmacologic approaches with nonpharmacologic therapy in the treatment of fibromyalgia (FM), especially stress management, aerobic exercise, and, in some cases, psychotherapy. Tricyclic antidepressants (TCAs) are of proven benefit.Certain anticonvulsants and antidepressants clearly decrease pain sensitivity.Corticosteroids and nonsteroidal anti-inflammatory medications are useful only as management for coexisting inflammatory processes.

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Most cases of GAD begin in childhood and can lead—without treatment—to a chronic condition, with fluctuating symptoms, often exacerbated by stressful life events.

Nonmalignant, chronic pain is associated with physical, emotional and financial disability.

Recent animal studies have shown that remodeling within the central nervous system causes the physical pathogenesis of chronic pain.

Patients with fibromyalgia have difficulty tolerating regular doses of most medications and supplements.

They are sensitive to medications, and adverse effects are common.

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